Tumor immune microenvironment in head and neck cancers

[The effect of the microenvironment of head and neck cancers on tumor progression].

In the last 20 years the incidence and mortality of head and neck squamous cell carcinomas showed an increasing rate in Hungary. In our work we examined the microenvironment of head and neck cancers localized in different anatomical regions. Clinical evidence shows that the prognosis of hypopharyngeal tumors is poorer than that of head and neck cancers in other anatomical locations. We investig...

Tumor Microenvironment in Head and Neck Squamous Cell Carcinomas.

Recent studies about solid tumors demonstrated that tumor microenvironment has an important role in tumor progression, aggressivity, and metastasis process, in addition to genetic aberrations and molecular alterations of cancer cells. Therefore, the crosstalks between cancerous and noncancerous cells and metabolic changes in tumor microenvironment cause significant detrimental effects. The purp...

Immune Suppression in Head and Neck Cancers: A Review

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the hos...

Head and neck cancers.

Pesticide Exposure and Head and Neck Cancers: A Case-Control Study in an Agricultural Region

Introduction: Causes of head and neck cancers (HNCs) are multifactorial, and few studies have investigated the association between chemical exposure and HNCs. The objective of this study was to investigate associations between HNCs, agricultural occupations, and pesticide exposure. The potential for the accumulation of pesticides in the adipose tissue of patients was also investigated.   Materi...